The human brain faces a difficult trade-off. On the one hand it needs to be complex to ensure high performance, and on the other it needs to minimise "wiring cost" — the sum of the length of all the connections — because communication over distance takes a lot of energy. It's a problem well-known to computer scientists. And it seems that market driven human invention and natural selection have come up with similar solutions.
Comparing and communicating small lethal risks is a tricky business, yet this is what many of us are faced with in our daily lives. One way of measuring these risks is to use a quantity called the micromort. David Spiegelhalter and Mike Pearson investigate.

The human genome is represented by a sequence of 3 billion As, Cs, Gs, and Ts. With such large numbers, sequencing the entire genome of a complex organism isn't just a challenge in biochemistry. It's a logistical nightmare, which can only be solved with clever algorithms.

"It's a match!" cries the CSI. At first glance it might seem that if the police have matched a suspect's DNA to evidence from the crime scene, then the case is closed. But some statistical thinking is required to understand exactly what a match is, and importantly, how juries should assess this as part of the evidence in a trial.

Martino Barenco and Mike Hubank shed light on suicidal cells and a mathematical model that could help fight cancer.

David Spiegelhalter explains that waiting for an infinite number of monkeys to produce the complete works of Shakespeare is not just a probabilistic certainty, it also gives us an insight into how long we can expect to wait for a rare event to happen.