It has nothing to do with a human observing anything. It has to do with how one observes things at the atomic and quantum scale. We make these observations by bouncing other particles off of the particles we're interested in examining. At the macro-scale this is not a problem as the particles were bounce off of things are much smaller and have little no affects at the macro.

But at the atomic and smaller scales, the particles we bounce off of things to observe them are similar in "size" (this is a stand in for mass, charge, etc.) to the particles we are trying to observe.

You can think of it like trying to figure out where a billiard ball is by bouncing a golf ball it. That will change the position, spin, etc. of the billiard ball.