medicine and health
London, September, 1853. A cholera outbreak has decimated Soho, killing 10% of the population and wiping out entire families in days. Current medical theories assert that the disease is spread by "bad air" emanating from the stinking open sewers. But one physician, John Snow, has a different theory: that cholera is spread through contaminated water. And he is just about to use mathematics to prove that he is right.
Infectious diseases hardly ever disappear from the headlines — swine flu is only the last in a long list containing SARS, bird flu, HIV, and childhood diseases like mumps, measles and rubella. If it's not the disease itself that hits the news, then it's the vaccines with their potential side effects. It can be hard to tell the difference between scare mongering and responsible reporting,
because media coverage rarely provides a look behind the scenes. So how do scientists reach the conclusions they do?
The human genome is represented by a sequence of 3 billion As, Cs, Gs, and Ts. With such large numbers, sequencing the entire genome of a complex organism isn't just a challenge in biochemistry. It's a logistical nightmare, which can only be solved with clever algorithms.